This video clip is from the South Park episode entitled “Ginger Kids.” South Park is an animated sitcom on Comedy Central about four boys in the fourth grade living in South Park, Colorado. In the clip, Cartman, one of the children on the show, goes on a tirade against Ginger Kids—kids with red hair, pale skin, and freckles—in a class presentation. He calls their condition “Gingervitus” and equates their appearance to a disease. He suggests that Ginger Kids should be feared and hated because they "have no souls" and that the “Ginger plague” should be removed from the earth.
Source: South Park